If you’ve considered egg donation, you’ve likely heard about AMH as part of the egg donor screening process used to determine suitability and eligibility to donate eggs.
What is AMH?
AMH, or anti-Müllerian hormone, is a glycoprotein hormone expressed by the granulosa cells surrounding ovarian pre-antral follicles and released into the bloodstream. In general, the more pre-antral follicles you have, the higher your AMH blood level, whereas the fewer pre-antral follicles you have, the lower your AMH blood level. Combined with other ovarian reserve assessment tools performed during the egg donor screening process, AMH can be used as a quantitative biomarker to predict your ovarian reserve, as well response to fertility medication.
What is a normal AMH level?
Because AMH is still considered by some to be a recent tool used to assess ovarian reserve, there are differing opinions amongst providers regarding the categorization of AMH levels. Most reproductive endocrinologists, however, agree that AMH levels are inversely proportional to age and directly proportional to antral follicle count. In general:
- Low AMH levels are those below 1.0 ng/mL, and may be indicative of low ovarian reserve and poor response to gonadotropin stimulation.
- Normal AMH levels are those that fall between 1.0-4.0 ng/mL.
- High AMH levels are those above 4.0 ng/mL, and may be indicative of polycystic ovarian syndrome.
Reproductive endocrinologists at fertility centers often consider minimum eligibility for egg donation with an AMH level of 2.0 ng/mL, though this may vary from clinic to clinic.
Looking for additional AMH facts?
While AMH can predict ovarian reserve and response to fertility medication, it cannot foretell egg quality. Further, while AMH levels are relatively constant throughout the month, levels may be impacted by the use of hormone contraceptives, with several studies showing lower AMH levels in women who use hormone contraceptives. In addition, studies have shown that baseline AMH levels vary across different races and ethnic backgrounds. And finally, while AMH helps determine ovarian reserve and response to fertility medication, it is not well-correlated with pregnancy potential or pregnancy outcome.
Whether you’re considering egg donation or simply curious about your hormonal health, AMH can be used as part of a more comprehensive panel of tests to help predict your overall reproductive potential.
Disclaimer: The content provided above is not intended for, nor should it be used as, a substitute for professional medical advice. It should not replace a conversation you have directly with your medical provider regarding your own AMH level or ovarian reserve. Prior to the commencement of your egg donation cycle, we strongly encourage you discuss your AMH level and ovarian reserve with your medical team.